Transdifferentiation of Human Fibroblasts to Endothelial Cells
نویسندگان
چکیده
منابع مشابه
Response to Letter Regarding Article "Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity".
BACKGROUND Cell fate is fluid and may be altered experimentally by the forced expression of master regulators mediating cell lineage. Such reprogramming has been achieved with the use of viral vectors encoding transcription factors. We recently discovered that the viral vectors are more than passive vehicles for transcription factors because they participate actively in the process of nuclear r...
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Transdifferentiation is the direct conversion from one somatic cell type into another desired somatic cell type. This reprogramming method offers an attractive approach for regenerative medicine. Here, we demonstrate that neonatal fibroblasts can be transdifferentiated into endothelial cells using only four endothelial transcription factors, namely, ETV2, FLI1, GATA2, and KLF4. We observed a si...
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ژورنال
عنوان ژورنال: Circulation
سال: 2015
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.113.007394